Stevioside Activates AMPK to Suppress Inflammation in Macrophages and Protects Mice from LPS-Induced Lethal Shock
نویسندگان
چکیده
منابع مشابه
LPS-induced genes and protects mice from lethal endotoxin shock
JEM © The Rockefeller University Press $8.00 Vol. 203, No. 1, January 23, 2006 15–20 www.jem.org/cgi/doi/10.1084/jem.20051753 15 Innate immune cell activation via Toll-like receptors induces the release of infl ammatory cytokines, chemokines, and mediators. A rapid and robust response of macrophages and dendritic cells is needed for the control and elimination of fast-growing microbial invaders...
متن کاملThalidomide protects mice against LPS-induced shock.
Thalidomide has been shown to selectively inhibit TNF-alpha production in vitro by lipopolysaccharide (LPS)-stimulated monocytes. TNF-alpha has been shown to play a pivotal role in the pathophysiology of endotoxic shock. Using a mouse model of LPS-induced shock, we investigated the effects of thalidomide on the production of TNF-alpha and other cytokines and on animal survival. After injection ...
متن کاملGSK3β Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock
BACKGROUND Glycogen synthase kinase 3beta (GSK3beta) is a ubiquitous serine/threonine kinase that is regulated by serine phosphorylation at 9. Recent studies have reported the beneficial effects of a number of the pharmacological GSK3beta inhibitors in rodent models of septic shock. Since most of the GSK3beta inhibitors are targeted at the ATP-binding site, which is highly conserved among diver...
متن کاملDual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we identify the MAPK phosphatase dual specificity phosphatase 1 (DUSP1) as an essential endogenous regulator of th...
متن کاملGene delivery of SOCS3 protects mice from lethal endotoxic shock.
Suppressor of cytokine signaling 3 (SOCS3) was reported as a feedback inhibitor of cytokine receptor signaling by inhibiting the JAK-STAT signal transduction pathway. We sought to test the anti-endotoxic septic shock effect of liposome mediated gene delivery of SOCS3 in a lethal endotoxic shock mouse model. BALB/c mice were injected intraperitoneally with 200 microg pcDNA3.1-SOCS3 cationic lipo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecules
سال: 2021
ISSN: 1420-3049
DOI: 10.3390/molecules26040858